The third time frame - the long-term researchThe long-term research in GENERI BIOTECH is based on our experiences with the synthesis of modifi ed oligonucleotides and on their use in various applications. Our goal is to obtain information which would lead to some of forms of protected intellectual property. The primary issue here is the use of oligonucleotides in therapy and diagnostics. The secondary goal is to discover properties of real samples of oligonucleotides, mainly in contrast with the commonly shared information. Our projects which are part of the long-term research stem entirely from the methodical base of GENERI BIOTECH. The particular issues here are represented by therapeutic oligonucleotides and their conjugates (particularly with photo-dynamically active substances) and physical/chemical properties of oligonucleotides, or DNA in general, and their use in nanotechnology (electronics, diagnostic chips). In connection with the solution of projects focused on this issue, we obtained plenty of experience with real properties of variously modified oligonucleotides and their analysis by means of various techniques (e.g. STM/AFM, MALDI-TOF). In our laboratories, we successfully introduced the MALDI-TOF technology for the analysis of variously modified DNA or for the detection of a single nucleotide polymorphism (SNP). In terms of potential cooperation, we are able to prepare a design and synthesis of both standard and
modifi ed oligonucleotides for various applications and their comprehensive analyses.
Our partnershipsOur partners in long-time frame of research are as follows: the Faculty of Pharmacy of the Charles University in Hradec Králové (dr. M. Miletín), Institute of Physics of the Academy of Sciences of the Czech Republic (dr. I. Kratochvílová), Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic (dr. B. Schneider), Faculty of Chemistry, Brno University of Technology (dr. M. Weiter), Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic (prof. S. Nešpůrek), University of Bremen, Germany (prof. D. Blohm), Miltenyi Biotec GmbH, Germany (dr. I. Johnson), Exiqon A/S, Denmark (dr. P.S. Nielsen) and others.
Finished and ongoing projects | CENTRUM FaF | Potential therapeutics structure and mechanism of action research centre | | AVCR ELEKTRO | Molecular nanosystems and nanoparticles: electric transport properties | | AVCR BIOKOM | Bioactive biocompatible surfaces and new nanostructured composites for medical and pharmaceutical applications | | FP6 NANO | GENSENSOR-NANOPARTS; Nano-biotechnical components of advanced bioanalytical microarray system |
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