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IVD kits for oncology

IVD kits for oncology

In the category of CE IVD kits for oncology, we present our comprehensive portfolio of products for one-step real-time RT-PCR detection and quantification of BCR-ABL1 fusion transcripts.

The BCR-ABL1 hybrid gene is the main product of the t(9;22)(q34;q11) translocation. Depending on the breakpoint in the BCR gene, three variants of the fusion gene have been characterized: MAJOR (M-bcr, e14a2, e13a2, also known as b3a2, b2a2), MINOR (m-bcr, e1a2), and MICRO (mu-bcr, e19a2, also known as c3a2). BCR-ABL1 transcripts are translated to the corresponding proteins: p210 (major), p190 (minor), and p230 (micro).

The MAJOR variant of BCR-ABL1 gene is found in more than 90 % of patients suffering from chronic myelogenous leukemia (CML). To monitor minimal residual disease (MMR), BCR-ABL1 transcripts are quantified to the copy number of the reference gene transcript (ABL1, GUSB). Efforts to standardize molecular monitoring of BCR-ABL1 MAJOR led to introduction of the laboratory recommendations (Cross at al., 2015) and to development of the international reporting scale (IS) which allows accurate comparison of results obtained by different laboratories.

gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR / ABL
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gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR / ABL 3243-048 3243-048 gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR/ABL 48 Price on Quote Add to Quote
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gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR / ABL 3243-096 3243-096 gb ONCO BCR-ABL MAJOR / ABL gb ONCO BCR-ABL MAJOR/ABL 96 Price on Quote Add to Quote
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gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB
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gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB 3249-048 3249-048 gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB 48 Price on Quote Add to Quote
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gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB 3249-096 3249-096 gb ONCO BCR-ABL MAJOR / GUSB gb ONCO BCR-ABL MAJOR / GUSB 96 Price on Quote Add to Quote
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gb ONCO BCR-ABL MINOR / ABL gb ONCO BCR-ABL MINOR / ABL 3247-048 3247-048 gb ONCO BCR-ABL MINOR / ABL gb ONCO BCR-ABL MINOR / ABL
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gb ONCO BCR-ABL MICRO / ABL gb ONCO BCR-ABL MICRO / ABL 3248-048 3248-048 gb ONCO BCR-ABL MICRO / ABL gb ONCO BCR-ABL MICRO / ABL
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STANDARD MMR BCR-ABL MAJOR STANDARD MMR BCR-ABL MAJOR 3280-004 3280-004 STANDARD MMR BCR-ABL MAJOR STANDARD MMR BCR-ABL MAJ
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gb ONCO BCR-ABL DETECT gb ONCO BCR-ABL DETECT 3246-048 3246-048 gb ONCO BCR-ABL DETECT gb ONCO BCR-ABL DETECT
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gb ONCO EGFR T790M gb ONCO EGFR T790M gb ONCO EGFR T790M gb ONCO EGFR T790M
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gb ONCO EGFR T790M gb ONCO EGFR T790M 3245-024 3245-024 gb ONCO EGFR T790M gb ONCO EGFR (T790M) 24 Price on Quote Add to Quote
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gb ONCO EGFR T790M gb ONCO EGFR T790M 3245-048 3245-048 gb ONCO EGFR T790M gb ONCO EGFR (T790M) 48 Price on Quote Add to Quote
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gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F)
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gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F) 3242-024 3242-024 gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F) 24 Price on Quote Add to Quote
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gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F) 3242-048 3242-048 gb ONCO JAK2 (V617F) gb ONCO JAK2 (V617F) 48 Price on Quote Add to Quote
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gb ONCO BRAF (V600) gb ONCO BRAF (V600) gb ONCO BRAF (V600) gb ONCO BRAF (V600)
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gb ONCO BRAF (V600) gb ONCO BRAF (V600) 3281-024 3281-024 gb ONCO BRAF (V600) gb ONCO BRAF (V600) 24 Price on Quote Add to Quote
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gb ONCO BRAF (V600) gb ONCO BRAF (V600) 3281-048 3281-048 gb ONCO BRAF (V600) gb ONCO BRAF (V600) 48 Price on Quote Add to Quote
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gb ONCO BRAF (V600E) gb ONCO BRAF (V600E) gb ONCO BRAF (V600E) gb ONCO BRAF (V600E)
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gb ONCO BRAF (V600E) gb ONCO BRAF (V600E) 3241-024 3241-024 gb ONCO BRAF (V600E) gb ONCO BRAF (V600E) 24 Price on Quote Add to Quote
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gb ONCO BRAF (V600E) gb ONCO BRAF (V600E) 3241-048 3241-048 gb ONCO BRAF (V600E) gb ONCO BRAF (V600E) 48 Price on Quote Add to Quote
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gb ONCO CLL gb ONCO CLL 3240-010 3240-010 gb ONCO CLL gb ONCO CLL
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