modified oligonucleotides

Modified oligonucleotides – options & examples

Our modified oligonucleotides cover end modifications at the 3′ and 5′ ends as well as internal positions.
We offer base analogs, spacers, fluorophores, quenchers, backbone changes and functional groups for applications such as antisense, sequencing, duplex stabilization, structural studies or click-chemistry conjugations.
All modifications are delivered with high purity and can be combined on request (where chemistry allows).

Popular modifications & use cases

• Universal/modified bases:
  2′-DeoxyNebularine,
  3-Deaza-dA
• RNA analogs for antisense:
  2′F-RNA,
  2′OMe-RNA
• 3′ end extension blockers:
  2′3′-ddC
• Halogenated bases for structural/X-ray work:
  5-Br-dC,
  5-I-dU
• Duplex T_m enhancers:
  5-(1-Propynyl)-dC,
  5-(1-Propynyl)-dU

Looking for labeled probes? See
RT-PCR dual-labeled probes
or browse all oligonucleotides.