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modified oligonucleotides

modified oligonucleotides

The most common modifications are at the end of the string – at the 3’ or 5’ end, or combined. The modifying molecule may be in the middle of the chain, the bases in the chain may be replaced by their analogs; spacers of different lengths and nature, functional groups or molecules may be inserted into the chain. Modified phosphate linkage may be in the chain in all or only in selected positions. Less frequent modifications or their combinations are recommended to be consulted first because there are many limitations for synthesis and for purification of the resulting product.

Thiol S-S

Thiol S-S Thiol S-S

It is used as an intermediate for further oligo modifications (attachment to special surfaces, conjugation). Thiol S-S may be attached to the 5' end of the oligonucleotide.

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Yakima Yellow

Yakima Yellow Yakima Yellow

Yakima Yellow may be attached either to the 5' end or the 3' end of the oligonucleotide.

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ATTO dyes

ATTO dyes ATTO dyes

ATTO dyes are a series of fluorescent dyes which provide all the crucial properties required for modern fluorescent technologies with spectral region from 350 nm in the UV to 750 nm in the near infrared.

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