We are an EN ISO 9001 and 13485 certified EU-located company manufacturing custom DNA oligos. We have been synthesizing custom DNA oligonucleotides since 1995. Every year our custom oligo synthesis services produce dozens of thousands of oligos in many categories: unmodified oligos, variously modified oligos, oligos with various types of purifications and for various purposes (biological techniques based mostly on PCR, NGS, biophysical studies etc.). We produce real-time PCR probes as well.
The know-how we acquired in custom DNA oligo synthesis during more than 25 years is implemented into the development of other products, especially CE IVD kits and Life Sciences products.
Our typical partners are end-users of the custom DNA oligos (customers mostly in CZ and SK), business partners and distributors. We are looking for business partners and/or distributors worldwide who can fit the portfolio of our products, either the whole or a part of it, into their sales strategy.
C8-Alkyne-dT It is used for conjugations based on the click chemistry principle. C8-Alkyne-dT may be attached anywhere within the oligonucleotide sequence except for the 3' end.
Phosphorothioates Phosphorothioates contain the exchange of one oxygen in the phosphate bond with sulfur. By exchanging oxygen for sulfur, the resistance of the oligonucleotide to nucleases increases.
Phosphate It can be linked to an oligonucleotide at the 5 'end and the 3' end. The 5 'end is used for ligation. The 3 'end serves as a 3' polymerase extension blocker.
Biotin dT Biotin dT is attached with a six carbon spacer at position 5 of the thymine circle. Biotin dT may be attached anywhere within the oligonucleotide sequence except for the 3' end.
8-Amino-dG May be attached anywhere within the oligonucleotide sequence except for the 3' end. 8-Amino-dG modified oligonucleotides are utilized for triplex formation, enabled by the presence of an additional amino group.
8-Amino-dA May be attached anywhere within the oligonucleotide sequence except for the 3' end. 8-Amino-dA modified oligonucleotides are utilized for triplex formation, enabled by the presence of an additional amino group.
D-spacer May be attached anywhere within the oligonucleotide sequence except for the 3' end. It is used to introduce a stable abasic position to the oligonucleotide chain.
Spacer C12 May be attached anywhere within the oligonucleotide sequence except for the 3' end. Repeated spacer attachment is possible.
Spacer 18 May be attached anywhere within the oligonucleotide sequence except for the 3' end. It is the longest spacer available within a single modification.
BBQ650 Quencher suitable for fluorophores having an emission wavelength range from 550 to 750 nm. BBQ-650 may be attached to the 5'end or the 3' end of the oligonucleotide.
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