We are an EN ISO 9001, 13485 and 17025 certified EU-located company manufacturing custom DNA oligos. We have been synthesizing custom DNA oligonucleotides since 1995. Every year our custom oligo synthesis services produce dozens of thousands of oligos in many categories: unmodified oligos, variously modified oligos, oligos with various types of purifications and for various purposes (biological techniques based mostly on PCR, NGS, biophysical studies etc.). We produce real-time PCR probes as well.
The know-how we acquired in custom DNA oligo synthesis during the last 25 years is implemented into the development of other products, especially CE IVD kits and Life Sciences products.
Our typical partners are end-users of the custom DNA oligos (customers mostly in CZ and SK), business partners and distributors mostly within EU. We are looking for business partners and/or distributors worldwide who can fit the portfolio of our products, either the whole or a part of it, into their sales strategy.
Symetric doubler It is used to introduce symmetric branching of the oligonucleotide. Symmetric doubler may be attached anywhere within the oligonucleotide sequence except for the 3' end.
5-Me-dC-Brancher It is used to introduce either symmetric or asymmetric branching of the oligonucleotide. 5-Me-dC-Brancher may be attached anywhere within the oligonucleotide sequence except for the 3' end.
Hexynyl It is used for conjugations based on the click chemistry principle. Hexynyl may be attached to the 5' end of the oligonucleotide.
C8-Alkyne-dC It is used for conjugations based on the click chemistry principle. C8-Alkyne-dC may be attached anywhere within the oligonucleotide sequence except for the 3' end.
C8-Alkyne-dT It is used for conjugations based on the click chemistry principle. C8-Alkyne-dT may be attached anywhere within the oligonucleotide sequence except for the 3' end.
Uaq It serves to increase duplex stability. UAG raises the melting temperature and specificity of hybridization probes. UAG may be attached to the 3' end of the oligonucleotide.
Trimethoxystilben It serves to increase duplex stability. Trimetoxystilbene raises the melting temperature by up to 10°C. Furthermore, it enables manufacturing of hybridization probes with greater affinity to complementary sequences. Trimethoxystilbene may be attached to the 5' end of the oligonucleotide.
Pyrene It serves to increase duplex stability. Pyrene raises the melting temperature by up to 10°C. Furthermore, it enables manufacturing of hybridization probes with greater affinity to complementary sequences. Pyrene may be attached to the 5' end of the oligonucleotide.
N6-Me-dA It is used to increase duplex stability. N6-Me-dA may be attached anywhere within the oligonucleotide sequence except for the 3' end.
Phosphorothioates Phosphorothioates contain the exchange of one oxygen in the phosphate bond with sulfur. By exchanging oxygen for sulfur, the resistance of the oligonucleotide to nucleases increases.
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