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OLIGO & PROBES

We are an EN ISO 9001, 13485 and 17025 certified EU-located company manufacturing custom DNA oligos. We have been synthesizing custom DNA oligonucleotides since 1995. Every year our custom oligo synthesis services produce dozens of thousands of oligos in many categories: unmodified oligos, variously modified oligos, oligos with various types of purifications and for various purposes (biological techniques based mostly on PCR, NGS, biophysical studies etc.). We produce real-time PCR probes as well.

The know-how we acquired in custom DNA oligo synthesis during the last 25 years is implemented into the development of other products, especially CE IVD kits and Life Sciences products.

Our typical partners are end-users of the custom DNA oligos (customers mostly in CZ and SK), business partners and distributors mostly within EU. We are looking for business partners and/or distributors worldwide who can fit the portfolio of our products, either the whole or a part of it, into their sales strategy.

8-Amino-dG

8-Amino-dG 8-Amino-dG

May be attached anywhere within the oligonucleotide sequence except for the 3' end. 8-Amino-dG modified oligonucleotides are utilized for triplex formation, enabled by the presence of an additional amino group.

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8-Amino-dA

8-Amino-dA 8-Amino-dA

May be attached anywhere within the oligonucleotide sequence except for the 3' end. 8-Amino-dA modified oligonucleotides are utilized for triplex formation, enabled by the presence of an additional amino group.

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Amino C6sp-dT

Amino C6sp-dT Amino C6sp-dT

May be attached anywhere within the oligonucleotide sequence except for the 3' end. The primary amino group is bound by a spacer to the pyrimidine circle of thymine.

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Amino N2-C6sp-dG

Amino N2-C6sp-dG Amino N2-C6sp-dG

May be attached anywhere within the oligonucleotide sequence except for the 3' end. The primary amino group is bound by a spacer to the purine circle of guanosine.

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Amino C6sp-dC

Amino C6sp-dC Amino C6sp-dC

May be attached anywhere within the oligonucleotide sequence except for the 3' end. The primary amino group is bound by a spacer to the pyrimidine circle of cytosine.

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PC-spacer

PC-spacer PC-spacer

A PC (Photo-cleavable) Spacer may be attached either between the oligonucleotide bases or between the oligonucleotide chain and its 5' end modifying group. UV iradiation at 300 - 350 nm cleaves the oligonucleotide to the portion carrying a spacer and the oligonucleotide with a 5' end phosphate modification.

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D-spacer

D-spacer D-spacer

May be attached anywhere within the oligonucleotide sequence except for the 3' end. It is used to introduce a stable abasic position to the oligonucleotide chain.

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Spacer C12

Spacer C12 Spacer C12

May be attached anywhere within the oligonucleotide sequence except for the 3' end. Repeated spacer attachment is possible.

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Spacer 18

Spacer 18 Spacer 18

May be attached anywhere within the oligonucleotide sequence except for the 3' end. It is the longest spacer available within a single modification.

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Eclipse

Eclipse Eclipse

Quencher suitable for fluorophores having an emission wavelength range from 480 to 580 nm. Eclipse may be attached to the 5'end or the 3'end of the oligonucleotide.

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Dabcyl

Dabcyl Dabcyl

Relatively weak quencher suitable for molecular beacons probes. Dabcyl may be attached to the 5' end or the 3'end of the oligonucleotide.

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BBQ650

BBQ650 BBQ650

Quencher suitable for fluorophores having an emission wavelength range from 550 to 750 nm. BBQ-650 may be attached to the 5'end or the 3' end of the oligonucleotide.

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