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OLIGO & PROBES

We are an EN ISO 9001, 13485 and 17025 certified EU-located company manufacturing custom DNA oligos. We have been synthesizing custom DNA oligonucleotides since 1995. Every year our custom oligo synthesis services produce dozens of thousands of oligos in many categories: unmodified oligos, variously modified oligos, oligos with various types of purifications and for various purposes (biological techniques based mostly on PCR, NGS, biophysical studies etc.). We produce real-time PCR probes as well.

The know-how we acquired in custom DNA oligo synthesis during the last 25 years is implemented into the development of other products, especially CE IVD kits and Life Sciences products.

Our typical partners are end-users of the custom DNA oligos (customers mostly in CZ and SK), business partners and distributors mostly within EU. We are looking for business partners and/or distributors worldwide who can fit the portfolio of our products, either the whole or a part of it, into their sales strategy.

Cy5

Cy5 Cy5

May be attached to the 5' end of the oligonucleotide. Oligonucleotide purification is a necessity.

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Cy3

Cy3 Cy3

May be attached anywhere within the oligonucleotide sequence except for the 3' end.

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TET

TET TET

Tetrachlorofluorescein is commonly used for multiplex reactions with FAM and HEX. It can be linked to an oligonucleotide at the 5 'end.

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HEX

HEX HEX

Hexachlorofluorescein is commonly used in multiplex reactions together with FAM and TET. Hexachlorofluorescein may be attached to the 5' end of the oligonucleotide.

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Fluorescein-dT

Fluorescein-dT Fluorescein-dT

Fluorescein dT is attached by a six carbon spacer at position 5 of the thymine circle. Fluorescein dT may be attached anywhere within the oligonucleotide sequence.

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Fluorescein

Fluorescein Fluorescein

It is a mixture of 5- and 6-carboxyfluorescein isomers. Fluorescein may be attached anywhere within the oligonucleotide sequence.

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6-FAM

6-FAM 6-FAM

Denotes pure 6-carboxyfluorescein isomer. This is among the most used oligonucleotide fluorescent modifications and is compatible with the majority of fluorescent devices. 6-FAM may be attached either to the 5' end or the 3' end of the oligonucleotide.

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CFR 610

CFR 610 CFR 610

CFR 610 is an orange-red fluorophore. It is also used as a good alternative to fluorophore Texas Red. CFR 610 may be attached only to 5´end of an oligonucleotide.

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Amino C6sp

Amino C6sp Amino C6sp

The amino group is bound to the 5' end of the oligonucleotide sequence by a six carbon spacer. It is used as an intermediate for further oligo modifications (attachment to special surfaces, conjugation).

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Spacer 9

Spacer 9 Spacer 9

May be attached anywhere within the oligonucleotide sequence except for the 3' end.

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Spacer C3

Spacer C3 Spacer C3

May be attached anywhere within the oligonucleotide sequence. Repeated spacer attachment is possible, forming a long hydrophobic arm. When bound to the 3' end it serves as a blocker of 3' polymerase extension.

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Amino C6sp-dA

Amino C6sp-dA Amino C6sp-dA

May be attached anywhere within the oligonucleotide sequence except for the 3' end. The primary amino group is bound by a spacer to the purine circle of adenosine.

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