Inside track

Our Science Club’s regular meetings provide an opportunity for our team to review the latest developments in research. The most recent meeting focused on the OncoPharm project. Our main focus this time was acute myeloid leukemia (AML). Unfortunately, successful treatment for patients with this disease is not always guaranteed. Everything depends on a very delicate

We are excited to announce that our team will be attending the European Human Genetics Conference in Gothenburg, Sweden. When? June 11 to 15th 2026. Join us to explore how our molecular diagnostic solutions support modern clinical and research applications, exchange ideas with our specialists, and discuss the future of genetic testing. You can meet

In modern molecular biology and clinical diagnostics, fluorescently labeled oligonucleotide probes constitute a crucial component of nucleic acid detection methods. While “native” dyes (e.g., those from the fluorescein or rhodamine families) have been historically established in standard protocols, recent advances in chemical synthesis provide a broad spectrum of alternative fluorophores that offer equivalent, and in

The UGT1A1 Promoter Polymorphism The most clinically relevant genetic variation in UGT1A1 involves the number of TA repeats in the promoter region (TATA box) of the gene: Allele TA Repeats Clinical Relevance UGT1A1*1 6TA Wild-type (normal enzyme activity) UGT1A1*28 7TA Reduced transcription and decreased enzyme activity UGT1A1*36 5TA Increased transcription (rare) UGT1A1*37 8TA Markedly reduced

Standard oligonucleotides reliably cover routine laboratory needs. However, more complex experimental designs—such as the preparation of long control templates, specific probes, or advanced genetic manipulations—often require sequences exceeding one hundred bases. To address these specific research applications, GENERI BIOTECH has expanded its portfolio with a new offering: ultramers. Standard Synthesis Parameters Ultramers are a targeted

At our regular monthly Science Club, we recently explored the principles and applications of digital PCR (dPCR). Together, we reviewed not only the theoretical foundations and technological differences compared to established quantitative PCR (qPCR), but also presented initial findings from our own testing and development efforts. Why dPCR? While conventional quantitative PCR (qPCR) relies on

Thiopurine S-methyltransferase (TPMT) is a crucial enzyme responsible for the inactivation of thiopurine drugs through S-methylation. These drugs — including azathioprine, mercaptopurine, and thioguanine — are widely used in clinical practice, especially in hematology, oncology, gastroenterology, and transplantology. Thiopurines are prodrugs that require metabolic activation to exert their cytotoxic or immunosuppressive effects. The balance between

We are pleased to announce that our team will be attending analytica 2026, the world’s leading trade fair for laboratory technology, analysis, and biotechnology, taking place in Munich. When? March 24–27, 2026 Where? Munich, Germany                  Hall 3 / Booth 129 Why meet with us? We will present

The microscope is no longer merely a device for visual inspection through an eyepiece; it is increasingly becoming a powerful source of digital data. Traditional optical observation is gradually being superseded by integrated digital systems that do not present images solely as visual outputs, but as fully quantifiable datasets. During a recent meeting of our

Today, we commemorate the International Day of Women and Girls in Science. While global statistics continue to highlight unequal representation in technical fields, here in Hradec Králové we are writing a very different story — a story in which expertise, molecular biology, and innovation bear women’s names in 89% of cases. Why Do We Celebrate

The year 2025 confirmed the growing trend of personalized medicine, in which molecular biological diagnostics is no longer an add-on but is becoming a standard tool for clinical decision-making. Take a look at which specific items from our portfolio might be useful for you.   Thrombosis Prevention and Metabolic Pathways – HEMO line The diagnosis

Backbone modifications alter the fundamental sugar–phosphate structure of an oligonucleotide. They are used to enhance stability, nuclease resistance, and binding affinity, making oligos suitable for demanding biological and therapeutic applications. Backbone modifications refer to chemical changes that affect the sugar–phosphate backbone of an oligonucleotide. These modifications alter the fundamental structure of the oligo rather than