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World Quality Day

World Quality Day

Every year, on the second Thursday of November, the world observes World Quality Day – an opportunity to pause and recognize that quality is not a one-time goal. It is a mindset, a way of working, and a culture that permeates the entire organization. In the field of biotechnology, quality plays an absolutely fundamental role.

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About oligos

What is a Universal Base in oligo?

What is a Universal Base in oligo?

A universal base is a modified nucleobase that can pair (non-selectively) with more than one of the standard DNA bases (A, T, G, C), ideally without significantly destabilizing the duplex or interfering with polymerase activity. Inosine is the most common universal base, although other possibilities exist: Common Universal Bases in Oligonucleotide Synthesis Name Description Base-Pairing

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About oligos

Inosine (I) vs. degenerate base “N” in oligo

Inosine (I) vs. degenerate base “N” in oligo

The degenerated base “N” and the universal base inosine (I) both serve to introduce base ambiguity in oligonucleotide synthesis, but they do so in different ways and are used in different contexts. Here’s a comparison: Inosine (I) vs. Degenerate Base “N” Feature Inosine (I) Degenerate Base “N” Chemical identity A real, single modified nucleotide A

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About oligos

Degen bases in oligo

Degen bases in oligo

Degen bases like dK and dP refer to synthetic, non-standard nucleobases used in molecular biology used in oligonucleotide synthesis — to allow degenerate (ambiguous) base pairing. They are alternatives to the classic “N” base, used to encode a mixture of A, T, G, C at a given position, but with greater control and performance in

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About oligos

Analog Bases in NGS: Expanding the Analytical Capabilities of DNA Analysis

Analog Bases in NGS: Expanding the Analytical Capabilities of DNA Analysis

Definition and Characteristics of Analog Bases Analog bases are chemically modified variants of the natural nucleotides—adenine (A), cytosine (C), guanine (G), and thymine (T)—that retain their ability to form complementary base pairs while exhibiting distinct chemical and structural properties. Within sequencing workflows, such modifications can minimize amplification bias, improve detection through enhanced fluorescent signaling, or

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Science Club Revival

Science Club Revival

At the end of August 2025, we returned to organizing our Science Clubs. These events were held regularly in the past decade, and after last year’s relocation and settling into our new premises, we realized that we were missing such a platform. A platform for education and discussion with elements of brainstorming—an opportunity to share

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