Inside track

Standard oligonucleotides reliably cover routine laboratory needs. However, more complex experimental designs—such as the preparation of long control templates, specific probes, or advanced genetic manipulations—often require sequences exceeding one hundred bases. To address these specific research applications, GENERI BIOTECH has expanded its portfolio with a new offering: ultramers. Standard Synthesis Parameters Ultramers are a targeted

At our regular monthly Science Club, we recently explored the principles and applications of digital PCR (dPCR). Together, we reviewed not only the theoretical foundations and technological differences compared to established quantitative PCR (qPCR), but also presented initial findings from our own testing and development efforts. Why dPCR? While conventional quantitative PCR (qPCR) relies on

Thiopurine S-methyltransferase (TPMT) is a crucial enzyme responsible for the inactivation of thiopurine drugs through S-methylation. These drugs — including azathioprine, mercaptopurine, and thioguanine — are widely used in clinical practice, especially in hematology, oncology, gastroenterology, and transplantology. Thiopurines are prodrugs that require metabolic activation to exert their cytotoxic or immunosuppressive effects. The balance between

We are pleased to announce that our team will be attending analytica 2026, the world’s leading trade fair for laboratory technology, analysis, and biotechnology, taking place in Munich. When? March 24–27, 2026 Where? Munich, Germany                  Hall 3 / Booth 129 Why meet with us? We will present

The microscope is no longer merely a device for visual inspection through an eyepiece; it is increasingly becoming a powerful source of digital data. Traditional optical observation is gradually being superseded by integrated digital systems that do not present images solely as visual outputs, but as fully quantifiable datasets. During a recent meeting of our

Today, we commemorate the International Day of Women and Girls in Science. While global statistics continue to highlight unequal representation in technical fields, here in Hradec Králové we are writing a very different story — a story in which expertise, molecular biology, and innovation bear women’s names in 89% of cases. Why Do We Celebrate

The year 2025 confirmed the growing trend of personalized medicine, in which molecular biological diagnostics is no longer an add-on but is becoming a standard tool for clinical decision-making. Take a look at which specific items from our portfolio might be useful for you.   Thrombosis Prevention and Metabolic Pathways – HEMO line The diagnosis

Backbone modifications alter the fundamental sugar–phosphate structure of an oligonucleotide. They are used to enhance stability, nuclease resistance, and binding affinity, making oligos suitable for demanding biological and therapeutic applications. Backbone modifications refer to chemical changes that affect the sugar–phosphate backbone of an oligonucleotide. These modifications alter the fundamental structure of the oligo rather than

The beginning of a new year at GENERI BIOTECH represents more than just a change in the calendar. It marks a time when our projects, manufacturing activities, and collaborations with partners both in the Czech Republic and abroad are fully reactivated. We have returned to full operational mode and are ready to build on everything

While HLA-B27 is by far the strongest and most well-known genetic marker linked with ankylosing spondylitis, several other genetic factors also contribute to disease susceptibility and can provide additional diagnostic or research insights. 1. HLA-B27 (primary marker) Present in ~90% of patients with AS of European ancestry. Not causative by itself — about 5–10% of

The human leukocyte antigen HLA-B27 is a variant of the class I major histocompatibility complex (MHC I) molecule. It is encoded by the HLA-B locus on chromosome 6 and expressed on almost all nucleated cells. Role in Health and Disease HLA-B27’s normal function is to present peptide antigens (derived from both self and non-self proteins)

Factor V’s role in coagulation Coagulation factor V is a key plasma glycoprotein in the blood-clotting cascade. In its activated form (Factor Va), it acts as a cofactor for Factor Xa, accelerating the conversion of prothrombin (Factor II) into thrombin. Thrombin then cleaves fibrinogen, resulting in fibrin formation — the fibrous mesh that gives structure to