IVD kits for pharmacogenetics

IVD kits for pharmacogenetics

We develop and produce kits that are used for in vitro genotypization before an appropiate treatment of disease starts. There application is important at selected drugs where extensive side effects may occur or where various types and speed of metabolism plays a decisive role in treatment.

gb PHARM TPMT gb PHARM TPMT

gb PHARM TPMT gb PHARM TPMT

The kit is intended for detection of TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C in TPMT gene in human genomic DNA by realtime PCR method (allelic discrimination). The kit allows the determination of haplotypes TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C in homozygous or heterozygous form. The kit does not distinguish genotype *1/*3A (two mutations in cis form) from 3B*/*3C (the incidence of the composite heterozygote *3B/3C* is unlikely in Caucasians).

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gb PHARM Warfarin gb PHARM Warfarin

gb PHARM Warfarin gb PHARM Warfarin

The kit is intended for detection of mutation CYP2C9*2, CYP2C9*3 and VKORC1 G1639A in human genomic DNA by real-time PCR method (allelic discrimination).

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gb PHARM DPYD*2A gb PHARM DPYD*2A

gb PHARM DPYD*2A gb PHARM DPYD*2A

The kit is intended for detection of mutation DPYD*2A (IVS14+1G>A) in gene for dihydropyrimidine dehydrogenase in human genomic DNA by real-time PCR method (allelic discrimination).

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gb PHARM CYP2C19 gb PHARM CYP2C19

gb PHARM CYP2C19 gb PHARM CYP2C19

Kit for detection of CYP2C19*2, CYP2C19*3 and CYP2C19*17 gene mutation. The detection principle is based on a real-time polymerase chain reaction (qPCR) using fluorescent labeled probes (allelic discrimination).

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gb PHARM UGT1A1 gb PHARM UGT1A1

gb PHARM UGT1A1 gb PHARM UGT1A1

The real-time PCR diagnostic kit allows detection of variants of 5TA (UGT1A1 * 36), 7TA (UGT1A1 * 28), 8TA (UGT1A1 * 37), and 211G / A SNP UGT1A1 polymorphisms. The detection is based on the Q-FRET probe and uses the analysis of melting curves for multiplex genotyping.

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