Oligonucleotide modification patents
Non-fluorescent phthalocyanine and azaphthalocyanine derivatives as fluorescence extinguisher (2008)
Use of phthalocyanines, naphthalocyanines, combined phthalocyanine / naphthalocyanines and their azaanalogues of formula I, wherein the individual substituents are of specific significance, for quenching fluorescence upon binding to a biomolecule, except for quenching fluorescence in-vivo, wherein the biomolecule may be a nucleic acid or peptide. conjugated to fluorophore.
Use of the above for the detection and quantification of fluorescently active molecules in a sample of biological material or tissue.
Azaphthalocyanines, azanaphthalocyanines and combined azaphthalocyanaphthalocyanines of the general formula II, where the individual substituents have a specific significance, their use for quenching fluorescence after binding to a biomolecule, except for quenching fluorescence in-vivo, where the biomolecule may be a nucleic acid or peptide that may be conjugated a fluorophore for the detection and quantification fluorescently active molecules in a biological material or tissue sample as well as a kit, wherein the compound of formula II is bound to a specific DNA / RNA sequence.
Owner of the patent:
GENERI BIOTECH, Faculty of Pharmacy (Charles University)