Oligonucleotide modification patents

Non-fluorescent phthalocyanine and azaphthalocyanine derivatives as fluorescence extinguisher (2008)

Patent Number

CZ300906

Annotation:

Use of phthalocyanines, naphthalocyanines, combined phthalocyanine / naphthalocyanines and their azaanalogues of formula I, wherein the individual substituents are of specific significance, for quenching fluorescence upon binding to a biomolecule, except for quenching fluorescence in-vivo, wherein the biomolecule may be a nucleic acid or peptide. conjugated to fluorophore.

Use of the above for the detection and quantification of fluorescently active molecules in a sample of biological material or tissue.

Azaphthalocyanines, azanaphthalocyanines and combined azaphthalocyanaphthalocyanines of the general formula II, where the individual substituents have a specific significance, their use for quenching fluorescence after binding to a biomolecule, except for quenching fluorescence in-vivo, where the biomolecule may be a nucleic acid or peptide that may be conjugated a fluorophore for the detection and quantification fluorescently active molecules in a biological material or tissue sample as well as a kit, wherein the compound of formula II is bound to a specific DNA / RNA sequence.

Owner of the patent:

GENERI BIOTECH, Faculty of Pharmacy (Charles University)