Detection method: one-step real-time PCR
CE IVD diagnostic kit enables detection and quantification of b2a2 (e13a2) and b3a2 (e14a2) BCR-ABL1 MAJOR fusion gene transcript variants. The detection is based on one-step RT-qPCR using fluorescently labelled probes. The quantification is evaluated as the copy number percentage ratio of BCR-ABL1 fusion transcripts to GUSB reference gene transcripts. The detection and quantification of both fusion and reference gene transcripts is performed in one tube.
The BCR-ABL1 MAJOR fusion gene variant occurs in 95% patients with chronic myelogenous leukemia (CML) and in 25% patients with acute lymphocytic leukemia (ALL). The chromosomal aberration leads to the dysregulation of the tyrosine kinase signaling pathway and to the manifestation of the oncological disease.
The response of the patient to the treatment and the minimal residual disease is monitored under recommendation through the quantification of the b2a2 (e13a2) and b3a2 (e14a2) BCR-ABL1 MAJOR fusion transcripts related to the reference gene transcripts. The conversion of the results into the International Scale (IS) units is enabled by using STANDARD MMR BCR-ABL MAJOR (cat. no. 3280-004), which is verified for such purpose by the National Reference Laboratory of the Institute of Hematology and Blood Transfusion, Prague.
| Cat. No. | Product | No. of reactions | Price |
|---|
| 3249-048 | gb ONCO BCR-ABL MAJOR / GUSB | 48 |
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| 3249-096 | gb ONCO BCR-ABL MAJOR / GUSB | 96 |
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1 CE IVD real-time PCR kit contains reagents to provide 48 or 96 PCR reactions of 25 μl volume each.
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General Terms and Conditions
Validated for:
CFX96/96Touch (Bio-Rad)
QuantStudio 5 (Applied Biosystems)
RG 3000 (Corbett Research)
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Products are dispatched within 10 business days upon receiving the order
Shipping
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Recommended storage
Storage at -20 °C
Expiry date
Product remains stable until expiry date stated on the product label (min. 6 months after delivery)
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