DNA genotyping
Genotyping is the process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence and comparing it to another individual's sequence or a reference sequence.
Genetic polymorphism of cytochrome 450 (CYP) drug-metabolizing enzymes leads to inter-individual variability in the plasma concentrations of many drugs. Inter-individual variability among patients is a major clinical problem, as it can cause serious adverse drug reactions or therapeutic failures. Therefore, knowledge of CYP genotypes is very useful in predicting individual phenotypes that will help clinicians in the selection of the most appropriate drug dosages in each patient. In particular, it is excellent for predicting who might be a candidate for high, normal or low doses of a certain drug, or who might not be a candidate for a certain drug at all.
Our client, a clinical research organization specializing in human clinical studies, inquired of GENERI BIOTECH the best approach of how to detect different CYP2A6 genotypes which are known to influence a response to an anti-cancer drug they wanted to investigate.
To optimally address the inter-individual CYP2A6 variability, our R&D department designed and developed 3 different genetic assays to cover all relevant CYP2A6 genotypes:
Published by: Kateřina Dolečková, Ph.D.
August 2019
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