Platelet glycoprotein GPIa forms a complex GPIa/IIa with glycoprotein GPIIa on the surface of blood platelets. One-nucleotide C807T mutation is one of the “silent” polymorphisms that do not change the amino acid sequence. However, the presence of the mutated form increases the gene expression.
Both, heterozygous and homozygous carriers of the mutated allele, have twice as many receptors on the platelet surface as compared to the wild type homozygotes, which causes an increased thrombocyte adhesivity to type 1 collagen. Under high shear stress in the arterial bed, increased thrombocyte adhesivity has thrombogenic potential. Both, heterozygous and homozygous carriage of the mutated allele, is considered to be a mild risk factor of myocardial infarction and stroke in younger people.
Parameters of the diagnostic kit
- ready-to-use assay
- sample concentration 1-100 ng/µl
- positive and negative controls included
- FAM and HEX channels detection
- identical amplification profile as gb HEMO, gb GENETIC, gb PHARM kits