Modification by group: Modified backbone
Position of modification: 3´, 5´, internal
2′-F-RNA is even more stable than 2′-O-methyl-RNA. 2′-F-RNA & RNA duplexes do not activate RNase H and are more stable (with higher Tm) than RNA & 2′-O-methyl-RNA duplexes. It serves mainly for antisense applications. May be attached anywhere within the oligonucleotide sequence.
| Cat. No. | Modification | Scale | Price |
|---|
| 1163 | 2'F-RNA | 40 nmol |
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| 1163 | 2'F-RNA | 200 nmol |
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Modification is limited and can be performed upon consultation; precise price quotation can be prepared after providing particular sequences.
Oligo price = price of sequence without modification + surcharge for modification
Shiping at ambient temperature from
€ 37 (EU)
For other destinations see
indicative list.
General Terms and Conditions
Dual-labeled hydrolysis probes The technology of dual-labeled hydrolysis probes (also called TaqMan® real-time PCR probes) exploits the 5 ́-3 ́ exonuclease activity of Taq DNA polymerase to cleave the probe. TaqMan real-time PCR probes are labeled with a fluorescent dye (reporter) at the 5´ end and with a quencher at the 3´ end.
Why choose alternative dyes instead of "genuine" dyes? First, they are cheaper, and second, they can give the same results. Another reason is that the number of suppliers who can provide modified oligonucleotides is restricted - only a patent or a licence owner is usually allowed to produce them.
Background Probiotics are defined as live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. For instance, probiotics can be used in the treatment and prevention of infections and chronic inflammatory disorders of the gastrointestinal tract. Due to their health attributes, probiotics generate considerable interest in the area of functional
The avermectins compose a class of polycyclic lactones that are used to treat parasitic worms and insect pests. They are naturally occurring compounds generated in a fermentation process by a soil actinomycete Streptomyces avermitilis.
Biodistribution (BD) studies are critical components when assessing the preclinical safety evaluation of cell and gene therapy molecules. BD analysis is generally conducted at the molecular level using a methodology that provides high sensitivity.
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Dispatch date
Minimum 3 weeks
Shipping
At room temperature
Storage recommendation
Dried oligonucleotides: at 4 °C (in a refrigerator)
Dissolved: -20°C (in a freezer), we recommend to store in aliquotes
Product expiry date
24 months form the date of manufacture (provided the product is stored as recommended)
The provided information is only indicative and is always subject to the specific content and extent of an order.
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