Modification by group: Modified backbone

Position of modification: 3´, 5´, internal

Compared to RNA 2′-O-methyl-RNA is more chemically stable (being stable against nucleases for several days). 2′-O-methyl-RNA & RNA duplexes do not activate RNase H and are more stable (with higher Tm) than DNA & RNA duplexes. It is used mainly in antisense applications. May be attached anywhere within the oligonucleotide sequence.

Cat. No. Modification Scale Price
1164 2'OMe-RNA 40 nmol
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1164 2'OMe-RNA 200 nmol
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Modification is limited and can be performed upon consultation; precise price quotation can be prepared after providing particular sequences.

Oligo price = price of sequence without modification + surcharge for modification

Shiping at ambient temperature from € 40 (EU)
For other destinations see indicative list.

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