Modification by group: Thiol modifier
Position of modification: 3´, 5´
It is used as an intermediate for further oligo modifications (attachment to special surfaces, conjugation) and as a blocker of 3′ polymerase extension. Thiol SH may be attached either to the 5′ end or the 3′ end of the oligonucleotide.
| Cat. No. | Modifikace | Scale | Price |
|---|
| 1115-040 | 5' THIOL SH | 40 nmol |
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| 1115-200 | 5' THIOL SH | 200 nmol |
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Oligo price = price of sequence without modification + surcharge for modification
| Cat. No. | Modifikace | Scale | Price |
|---|
| 1137-200 | 3´- THIOL SH | 200 nmol |
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| 1137-001 | 3´- THIOL SH | 1 micromol |
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Dual-labeled hydrolysis probes The technology of dual-labeled hydrolysis probes (also called TaqMan® real-time PCR probes) exploits the 5 ́-3 ́ exonuclease activity of Taq DNA polymerase to cleave the probe. TaqMan real-time PCR probes are labeled with a fluorescent dye (reporter) at the 5´ end and with a quencher at the 3´ end.
Why choose alternative dyes instead of "genuine" dyes? First, they are cheaper, and second, they can give the same results. Another reason is that the number of suppliers who can provide modified oligonucleotides is restricted - only a patent or a licence owner is usually allowed to produce them.
Background Probiotics are defined as live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. For instance, probiotics can be used in the treatment and prevention of infections and chronic inflammatory disorders of the gastrointestinal tract. Due to their health attributes, probiotics generate considerable interest in the area of functional
The avermectins compose a class of polycyclic lactones that are used to treat parasitic worms and insect pests. They are naturally occurring compounds generated in a fermentation process by a soil actinomycete Streptomyces avermitilis.
Biodistribution (BD) studies are critical components when assessing the preclinical safety evaluation of cell and gene therapy molecules. BD analysis is generally conducted at the molecular level using a methodology that provides high sensitivity.
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Dispatch date
Term A: products are dispatched within the next 2 full business days after receiving the order
Term B: products are dispatched within the next 5 full business days after receiving the order
Shipping
At room temperature
Storage recommendation
Dried oligonucleotides: at 4 °C (in a refrigerator)
Dissolved: -20°C (in a freezer), we recommend to store in aliquotes
Product expiry date
24 months form the date of manufacture (provided the product is stored as recommended)
The provided information is only indicative and is always subject to the specific content and extent of an order.
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