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Phosphorothioates

Phosphorothioates

Modification by group: Modified backbone

Position of modification: internal

Phosphorothioates contain the exchange of one oxygen in the phosphate bond with sulfur. By exchanging oxygen for sulfur, the resistance of the oligonucleotide to nucleases increases.


pure phosphorothioates: substitution is made in all phosphate linkages in the chain
mixed phosphorothioates: substitution is only made on selected phosphate bonds.

Phosphorothioates are used for antisense applications where a 10 μmol scale is usually selected.

Cat. No. Modifikace Scale Price
1160-020 Phosphorothioates 20 nmol
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1160-040 Phosphorothioates 40 nmol
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1160-200 Phosphorothioates 200 nmol
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1160-001 Phosphorothioates 1 micromol
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1160-010 Phosphorothioates 10 micromol
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Oligo price = price of sequence without modification + surcharge for modification

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